Animal Research

The 14-story Heart Institute, completed in 2020 at the University of South Florida (USF), is the culmination of years of planning with an emphasis on integrating best practices from previous construction and renovation projects. The result is a “facilitative environment that provides for collaboration between researchers and research disciplines,” says Robert W. Engelman, associate vice president of research and innovation and professor of pediatrics, pathology, and cell biology at USF.

Pfizer is expanding its Chesterfield campus with the construction of a $60 million addition to support vaccine research and development. Providing leading-edge labs, offices, and support spaces, the three-story, 37,000-sf project will adjoin an existing 261,000-sf facility that opened in 2019. A two-story bridge with a covered plaza will link the completed structure to the rest of the 31-acre site. 

The need for more space to accommodate a daily backlog of unwashed cages sparked a $40 million gut renovation of the two-building animal research facility on the campus of the Armed Forces Radiobiology Research Institute (AFRRI) in Bethesda, Md. When the conjoined structures reopen this fall, they will be fully equipped with up-to-date features that facilitate animal care compliance, promote employee satisfaction, and offer uber-flexibility.

Colorado State University opened the Terra Building in Denver in June of 2022. Located on the Spur campus, the 60,000-sf facility offers immersive environments for agricultural research, education, and outreach. Featuring state-of-the-art laboratories and plant growth chambers, the sustainably designed project includes a teaching and culinary kitchen, sensory testing areas, classrooms, a K-12 discovery center, and venues for events and performances.

The Sixth Edition of the Biosafety in Microbiological and Biomedical Laboratories (BMBL) manual emphasizes the importance of risk assessment and management, communication among all stakeholders, comprehensive procedures to report accidents and exposures, and a new focus on biocontainment of pathogens affecting agricultural animals. First published in 1984, the BMBL still serves as the cornerstone of biosafety practices for the safe conduct of research throughout the world.

Elanco Animal Health broke ground in April of 2022 on its global headquarters campus in Greenfield, Ind. Designed by RATIO Architects and CSO to serve as the foundation of a planned animal health epicenter, the $100 million complex will support collaborative R&D with business incubator High Alpha and AgriNovus, the state of Indiana’s food and agriculture initiative.

The University of Wyoming opened the $100 million Science Initiative Building in March of 2022 in Laramie. Designed by GSG Architecture and Perkins&Will, the 153,000-sf structure will enhance interaction among multiple disciplines by collocating researchers into a single complex with shared core facilities. Located on the first floor to mitigate vibration, the Center for Advanced Scientific Instrumentation provides electron microscopes, an X-ray refractometer, a mass spectrometer, and micro CT scanners.

Piramal Pharma Solutions broke ground in February of 2022 on a £45 million antibody drug conjugate (ADC) facility in Grangemouth, Scotland. Accommodating both manufacturing and aseptic fill/finish operations, the structure will provide additional capacity for the creation of targeted cancer treatments and other innovative therapies. Representing an expansion of Piramal's existing ADC campus, the project is being delivered by Merit using its FlexiPOD V4.0 platform.

While creating generic/flexible lab spaces that can be adapted to a variety of different research needs continues to be the preferred approach—especially in higher education buildings—there is also a growing need for highly specialized lab and support facilities designed for very specific types of research. As a result, facility designers are increasingly tasked with balancing the demand for both open generic/flexible labs and specialized lab spaces in a single building with the added challenge of improving energy efficiency, sustainability, and operating costs.

Washington University School of Medicine will break ground in spring of 2022 on a $150 million vertical expansion of the Steven & Susan Lipstein BJC Institute of Health in St. Louis. Designed by Lawrence Group to promote collaboration and discovery, the six-story, 160,000-sf addition will provide 103,000 sf of biomedical research space and a 7,900-sf BSL-3 laboratory for the study of infectious diseases such as SARS-CoV-2 and tuberculosis.

Texas Biomedical Research Institute broke ground in December of 2021 on a $15 million nonhuman primate complex in San Antonio. Part of the Southwest National Primate Research Center, the four-building expansion will feature three large structures offering indoor and outdoor housing environments. An 18,000-sf animal care facility will provide a state-of-the-art veterinary clinic, pathology labs, and a staff meeting hub.

Pennsylvania State University opened the $98.5 million Animal, Veterinary and Biomedical Sciences Building in December of 2021 in University Park. Designed by HOK, the 105,000-sf facility provides the College of Agricultural Sciences with a state-of-the-art vivarium, a general-purpose classroom capable of accommodating 100 students, a 48-seat seminar room, and faculty offices.

The University of Massachusetts Chan Medical School is constructing the $325 million New Education and Research Building in Worcester. Designed by ZGF Architects and ARC/Architectural Resources Cambridge, the 350,000-sf facility will house the departments of neurology and neurobiology, a gene therapy center, and programs in animal research, molecular medicine, and human genetics and evolutionary biology.

Rocky Mountain Laboratories began construction in December of 2021 on a $93 million animal research vivarium in Hamilton, Mont. Accelerating the detection and mitigation of emerging infectious diseases, the 120,000-sf structure will provide climate-controlled environments for rodents, ticks, bats, and other species. The technology-rich building will also house an analytical lab and collaborative workspaces for researchers and staff.

Individually ventilated cage (IVC) systems are the standard for housing laboratory rodents, and, while research publications commonly refer to the use of IVCs in rodent-based studies, there are considerable differences in their mechanical design and operation that make a generalized, catch-all term problematic. This ambiguity has significant implications in certain research fields for ensuring consistency and the need to reproduce findings. As a result, a growing number of researchers are proposing inclusion of key details in the materials and methods section of published manuscripts to clarify the wide array of available IVC technologies, operating configurations, and performance variables.