Laboratory

From cortisone to CAT scans, the future of medicine has often arrived first at the Mayo Clinic. The tradition continues today with the fit-up of a new headquarters for regenerative biotherapeutics adjacent to the research center’s Rochester, Minn., campus. The fourth floor of the recently built Discovery Square building, Two Discovery Square, had been earmarked originally for office space, but after COVID hit, the developer offered the opportunity to convert some of the office space to laboratory space. Mayo Clinic had been planning to build a Center for Regenerative Biotherapeutics and saw an opportunity to lease the 18,000-sf space at Discovery Square and convert it for this cutting-edge biomanufacturing facility.  

Dallas County Health and Human Services opened its new Public Health Laboratory in March of 2026. Strategically sited in the Southwestern Medical District, the $52 million facility offers state-of-the-art environments for the detection and mitigation of infectious agents and toxins. The 67,000-sf building centralizes lab services previously dispersed in several locations while significantly increasing capacity for testing, disease surveillance, and emergency response.

The 1,235-acre University of Maryland (UMD) campus in College Park sits just eight miles from the nation’s capital. Founded in 1856 as a land-grant institution, the university offers 300 degree programs through 12 colleges serving 41,000 students and—together with the University of Maryland, Baltimore—has $1.4 billion in sponsored research expenditures. Over the past decade, the school has experienced many shifts, including joining the Big Ten Conference and receiving its largest donation in university history.

In a higher education landscape facing shifting enrollment trends, rising costs, and an uncertain future, institutions must rethink how they use their physical spaces—not just as real estate, but as engines of purpose. And rather than traditional return on investment (ROI), they should employ “Return on Mission” to evaluate their success rather than metrics like net-to-gross ratios, utilization rates, and physical occupancy to assess their spaces. Relying solely on ROI falls short of capturing what truly matters: the activity inside the space and the value it generates.

The ideal lab building can flex over time to accommodate each new generation of researchers, with minimal disruption and infrastructure change. Using an approach called the “resilient chassis,” labs are grouped by typologies and placed around a common spine or “chassis” of mechanical/electrical/plumbing (MEP) systems based on zoning and capacity needs. The best location for each lab is determined by grouping labs together that share specialized requirements, such as vibration sensitivities, noise restrictions, lighting or electrical requirements, and instrumentation needs. 

Faced with growing demand to do more with less, animal laboratory managers are looking for opportunities to drive greater efficiencies. One way forward is the use of digitalization to improve energy efficiency as well as asset and space utilization. But tight budgets, the need to improve data collection and analysis, and insufficient numbers of staff trained to operate the new systems are all holding back adoption, according to experts at Siemens Smart Infrastructure. 

When it was proposed in 2019, repurposing underutilized space at the University of Georgia for an industry partner’s fermentation lab appeared to be a good deal for everyone involved. It was a win for the pharmaceutical company that wanted to contract with the university to help it develop new products and needed a fermentation lab that met, at a minimum, biosafety level 2 (BSL-2) standards. It was a plus for staff at the university’s Bioexpression and Fermentation Facility who would perform the work. It represented an advance for the university that wanted to form new industry relationships and had available space at its Athens, Ga. campus inside the Animal Health Research Center (AHRC). And it was a win for the AHRC, a 75,000-sf biocontainment facility that would host a new industry partner in addition to other laboratories performing BSL-2, animal biosafety level 2 (ABSL-2), biosafety level 3 (BSL-3), animal biosafety level 3 (ABSL-3), and animal biosafety level 3-agricultural (ABSL-3Ag) research work.

Artificial intelligence is no longer a futuristic concept; it’s a transformative force actively reshaping how research is conducted, how buildings are designed, and how energy is consumed. From self-driving labs—defined as laboratories where scientific systems can autonomously perform multiple cycles of the scientific method—to smart energy systems, AI is ushering in a new era of efficiency, collaboration, and complexity. This shift was evident in a series of think tank sessions hosted by SmithGroup’s Science & Technology, Artificial Intelligence, and Energy Advisory Board, where leaders from academia, private industry, the energy sector, design, engineering and planning explored the rapid evolution of AI and its impact on research environments. In just six months between sessions, the pace of change was striking: Half of the experts expressed openness to selective technological enhancements, an idea nearly all had rejected earlier. This growing acceptance signals a more tangible AI-driven future, though strategies around governance and energy are still emerging. The following report offers insights into how AI is transforming research ecosystems, the energy infrastructure needed to support this growth, and the challenges and opportunities ahead.

Texas Tech University Health Sciences Center El Paso is constructing a $156 million comprehensive cancer hub and a $186 million clinical sciences building to ensure access to treatment throughout the West Texas region and enhance patient outcomes. The Steve and Nancy Fox Cancer Center is being created in partnership with University Medical Center of El Paso, and is supported by over $130 million in state funding and a $30 million county bond.

In an era of expanding research portfolios and heightened expectations for interdisciplinary collaboration, universities face intensifying pressure to strategically plan, manage, and optimize research space. Research facilities, wet labs, maker spaces, core facilities, and computational suites, represent some of the most limited and costly assets in the academic environment. As competition for high-quality laboratories and specialized rooms grows, institutions are re-evaluating entrenched practices, strengthening policy frameworks, and adopting data-driven systems to ensure that space is allocated efficiently, transparently, and equitably. The most successful universities treat research space not as a static inheritance but as a strategic resource that must evolve with the institution’s mission.

More and more universities are building their scientific research centers around cores of huge, heavy, yet surprisingly delicate equipment. Building a core laboratory facility forces architects and campus planners to think about logistics, timing, and backup systems to a level of detail probably more familiar to NASA engineers than institutional architects. As the team behind Emory University’s new Health Sciences Research Building II (HSRB-II) learned, a huge range of factors—in their case, everything from the amount of rebar in the flooring to the width of the corridors to shipping velocity on the Suez Canal—must be reckoned with before such a facility is completed.

The University of Louisville's J.B. Speed School of Engineering opened the Student Success & Research Building in September of 2025 in Kentucky. The 114,000-sf facility was designed by SmithGroup and Luckett & Farley to offer a maker space, modern classrooms, laboratories, conference rooms, and teamwork areas.

Merck opened a filter and membrane manufacturing facility in October of 2025 in Cork, Ireland. Offering 32,291 sf of cleanroom space, the €150 million ($174.5 million) building will meet global demand in the production process of vaccines and life-changing biomedical treatments, including monoclonal antibodies and cell and gene therapies. By locating these expanded manufacturing capacities in Europe, Merck aims to reduce cross-border dependencies and ensure reliable access to critical filtration technologies.

The College of Eastern Idaho is constructing the Future Tech building on the Idaho Falls campus. The $50 million facility will leverage connections with the region’s institutional and industry leaders to realize advances in energy resources, sustainability practices, and technological applications, while providing hands-on training to address growing workforce demands in those fields.

Rice Real Estate Company and Lincoln Property Company are planning to construct a landmark research facility in the Ion District in Houston. Designed by HKS, the Arc will connect academic excellence with industry, institutional, and entrepreneurial partners to accelerate the transition of science and technology discoveries to the marketplace.