Genomics

The vision of biomedical research as a collective effort is resoundingly clear in the $237.5 million Pelotonia Research Center, the first building to be completed in the 350-plus-acre Carmenton district on the campus of The Ohio State University (Ohio State) in Columbus. Opened in May 2023, the center integrates almost 100,000 sf of wet labs, 25,000 sf of computational labs, and 20,000 sf of core labs in a single facility designed to host interdisciplinary collaborations and public-private initiatives that focus on solving some of the most critical health challenges. With life science as the backbone of the research endeavor, current projects range from modeling cancer progressions to 3D printing of patient-specific anatomic models. 

The Sam and Ann Barshop Institute for Longevity and Aging Studies at the University of Texas Health in San Antonio illustrates the pivotal role location plays in enhancing the success of an internationally recognized research program. The Institute previously occupied two buildings at a research park 23 miles from the university’s main campus. University administrators wanted to collocate all research on the same campus to promote multidisciplinary collaboration and interaction, with proximity to all clinical research activities, and to promote efficiency and the shared use of resources. 

The University of Massachusetts Chan Medical School opened the $325 million New Education and Research Building in June of 2024 in Worcester. ZGF Architects and ARC/Architectural Resources Cambridge designed the 350,000-sf project to drive discovery in gene therapy, molecular medicine, and the neurosciences, as well as housing the departments of neurology and neurobiology.

Columbia University broke ground in late May of 2024 on the first all-electric biomedical research building in New York City. Designed by KPF, the 77,000-sf facility will drive innovation in genetic and genomic science to create new treatments for some of the most significant threats to human health today. The eight-story structure will feature state-of-the-art laboratories linked by "collaboration corners" with welcoming lounges for informal interaction and exchange.

The use of animals in biomedical research, already a decades-long ethically charged issue, has come under fire in more recent years for both a lack of scientific rigor and its huge financial appetite. Concerns about waste in basic research—in animal lives, scientist time, and research costs—are mounting, particularly when investigators are unable to confirm the data and achieve the same results when replicating original experiments (either theirs or others’). The solution? Track the effects of extrinsic environmental factors that can impact an animal's behavior, health, and reproduction: temperature, humidity, light, noise, and vibration.

Imperial College London opened the £120 million Laboratory of Medical Sciences in January of 2024 on the Hammersmith Hospital Campus. Designed by Hawkins\Brown to support team science, this collaborative hub for translational research accommodates programs in genetics, sex-based disease differences, and heart and metabolic disorders. The 130,000-sf structure features highly controlled lab environments carefully interwoven with comfortable write-up spaces and shared amenities.

The University of Virginia broke ground on the $350 million Paul and Diane Manning Institute for Biotechnology in December of 2023. Located in the Fontaine Research Park in Charlottesville, the 350,000-sf project will drive innovation in the fields of cellular therapy, gene therapy, nanotechnology, and drug delivery. By collocating state-of-the-art labs and core facilities with advanced manufacturing suites and clinical environments, the four-story building will accelerate the translation of medical discoveries into new solutions for patient care.

Ancora L&G began construction in August of 2023 on a $195 million life sciences center in Providence that will provide 80,000 sf of world-class research space for the Rhode Island Department of Health. Occupying the entirety of the second and third floors, the new state health lab will feature BSL-3 suites for the detection and mitigation of infectious disease agents and environmental hazards.

Canary Wharf Group and Kadans will break ground in fall of 2023 on One North Quay, a £500 million life sciences center in London. Designed by KPF, the 823,000-sf tower will provide world-class lab and office environments for biomedical and pharmaceutical companies. Constructed to the highest technological standards, the 23-story vertical campus will leverage advanced infrastructure to accommodate the stringent demands of wet-bench chemistry and high-containment research programs.

CellCarta, a leading provider of medical laboratory services, is partnering with developer Jadco to create a 450,000-sf life sciences center in Montreal. The $350 million project will transform the former site of the Montreal Chest Institute into Inspire Bio Innovations, a biomedical hub that will catalyze the development of new therapies and precision medicine technologies.

The University of Texas Health Science Center at Houston broke ground in June of 2023 on a $299 million facility for the School of Public Health. Located in the Texas Medical Center’s Helix Park, the 350,000-sf tower will provide leading-edge research labs, collaboration spaces, and classrooms for programs in epidemiology, genetics, nutrition, health policy, data science, and health promotion. Featuring an expansive auditorium, the 10-story building will integrate advanced distance-learning technologies to enable both in-person and remote instruction.

Ultragenyx opened a 110,000-sf gene therapy manufacturing facility in June of 2023 in Bedford, Mass. Advancing the creation of innovative treatments for rare genetic diseases, the sophisticated structure enables the large-scale manufacture of clinical-stage materials and approved products based on adeno-associated viral vectors (AAV). The highly efficient building integrates the company's proprietary Pinnacle PCL™ (producer cell line) platform which delivers optimal quality and scalability while reducing costs.

Stellenbosch University opened the $66 million Biomedical Research Institute (BMRI) in Cape Town in April of 2023. Located on the Tygerburg Campus, the 354,000–sf complex leverages an open design to foster active collaboration between researchers, staff, and students as they investigate the diseases that have the greatest impact on South Africa. Housing the Centre for Epidemic Response and Innovation, this high-performance research hub features a BSL-3 laboratory spanning 6,500 sf, the largest on the continent.

Repurposing non-research facilities to house specialized life sciences and therapeutics labs is a growing trend sparked by real estate inventory and the fiscal practicality of renovation rather than new construction. The vacancy rate throughout the United States for lab space in the fourth quarter of 2022 was 6 percent versus 19.5 percent for office space, according to the Jones Lang LaSalle real estate transparency index. The vacancy rates for 2021 were less than 4 percent for labs and approximately 15 percent for offices.

Icahn School of Medicine at Mount Sinai is constructing the 65,000-sf Hamilton and Amabel James Center for Artificial Intelligence and Human Health in New York. Designed by HOK, the project includes the redevelopment of a former nursing residence into a world-class research hub that will drive innovation in genomics, precision imaging, and multiscale disease modeling. The 12-story facility will become the first of its kind within a U.S. medical school when it opens in late 2023.