The Core Labs at King Abdullah University of Science and Technology (KAUST) in Saudi Arabia are run as a centrally governed “one lab” facility. In addition to successfully providing state-of-the-art equipment, training, and services to students, researchers, faculty, staff, industry partners, and collaborators, the core labs extend their services to external users, such as government organizations, research institutes, and other universities. By centralizing the business operations of 10 specialized labs, the model fosters collaboration, rationalizes necessary square footage, improves access to equipment and services, and eliminates duplication of resources, thus enhancing overall efficiency and reducing expenditures.