Biocontainment

Memorial University of Newfoundland is building the CAD$36 million Animal Resource Centre in St. Johns. Replacing two existing buildings, the collaborative 26,000-sf research facility will include rodent production and housing areas, surgical suites for small and large animals, physiological testing areas, and an Animal Containment Level 2 environment for behavioral studies. The project was designed by NXL Architects and will accommodate mice, rats, woodchucks, and Yucatan minipigs.

Cambrex Corporation, a leading manufacturer of small molecule innovator and generic Active Pharmaceutical Ingredients (APIs), completed an expansion of its pilot plant in High Point in May of 2018. The project included the installation and commissioning of a fourth reactor suite, increasing the site's capacity by approximately 30 percent. The 400-sf suite houses two 2,000-liter glass-lined reactors and a Hastelloy C22 filter dryer, allowing the manufacture of batch sizes between 10 and 100 kilograms under cGMP conditions.

The University of Plymouth opened the £17 million Derriford Research Facility in May of 2018 in the United Kingdom. Sited adjacent to the Peninsula Schools of Medicine and Dentistry at Plymouth Science Park, the 25,000-sf building is the headquarters of the Institute of Translational and Stratified Medicine.

Zoetis broke ground in April of 2018 on a 463,000-sf animal vaccine center in Suzhou, China. Combining research and development operations with integrated manufacturing and supply, the facility will produce vaccines for swine, cattle, fish, and companion animals. Offering sophisticated innovation suites and certified GMP laboratories, the project will support research on disease threats prevalent in China with a primary focus on aquaculture.

The University of Cambridge opened a £60 million facility for the Department of Chemical Engineering and Biotechnology in April of 2018 in the United Kingdom. Designed by BDP to promote collaboration and interaction, the 118,400-sf facility features a central atrium, BSL-2 and BSL-3 biological laboratories, cleanrooms, laser labs, optical and imaging suites, and a magnetic resonance research center.

A new approach to the design of diagnostic labs in resource-constrained settings reduces risk and improves outcomes while accelerating the project timeline and lowering costs. The approach is based on the concept of One Prototype, which uses similar design modules as a starting point for each lab facility, whether new construction or renovation, no matter what the scale.

The Canadian Food Inspection Agency will invest $80 million to construct a new Centre for Plant Health in Sidney, British Columbia. Replacing the existing 48-building campus, the project will provide advanced quarantine, testing, and diagnostic facilities for the detection and study of plant pathogens. Supporting innovative plant science research programs, the center will enhance the security and economic vitality of Canada's agricultural industry.

The University of Otago is constructing a NZD$50 million animal research building on its south campus in Dunedin, New Zealand. Located near the School of Medicine, the five-story, 42,367-sf facility will feature advanced technologies to optimize the welfare of the mice, rats, guinea pigs, birds, and pigs utilized in the University's research programs. Construction began in August of 2016 and completion is expected in early 2019. 

Aldevron is building a $30 million plasmid manufacturing facility in Fargo, N.D. The 70,000-sf project will feature 17,000 sf of modular cGMP cleanrooms, as well as ISO 8 processing suites with ISO 7 suites for cell banking and fermentation. The facility will feature airlocked, unidirectional personnel flow within the cGMP production area, single-pass air for all product dispensing and cell banking suites, and integrated facility and environmental monitoring systems.

Fraunhofer Institute for Cell Therapy and Immunology opened the Project Centre for Biomedical Engineering and Advanced Manufacturing (BEAM) in March of 2018 in Hamilton, Ontario. Located in the McMaster Innovation Park, the $33 million project involved the renovation and fit-out of an existing warehouse to create a 20,000-sf innovation center offering research, office, and manufacturing space. An additional 20,000 sf on the second floor will house laboratories and offices in the future.

Taconic Biosciences, a breeder of mice and rats for medical research, opened its 8,000-sf headquarters in February of 2018 in East Greenbush, N.Y. Located in the Cancer Research Center Building on the University at Albany Health Sciences campus, the facility is strategically sited to optimize relationships with key stakeholders and customers. The space houses the company's leadership team, as well as members of its product strategy, marketing, human resources, finance, quality, customers service, and business technology units.

Boston University's National Emerging Infectious Diseases Laboratories (NEIDL) has received final approval from the Boston Public Health Commission to conduct research at Biosafety Level 4 (BSL-4).  After years of scrutiny by regulatory agencies and city, state, and federal officials, the $200 million laboratory will now be able to work with approved BSL-4 pathogens such as Ebola and Marburg.

Georgia State University is planning to construct a $35 million biocontainment research facility in Atlanta. Located on the Downtown campus, the 55,000-sf building will provide BSL-3 and BSL-4 laboratories for the study of infectious diseases and select agents. The project, which will be the first academic BSL-4 facility in the Southeast, will include open research labs, offices, and support space. 

The Wuhan Institute of Virology began operations in its BSL-4 laboratories in January of 2018. Supporting research on infectious diseases and select agents, the biocontainment facility will enable scientists to develop innovative strategies for the detection and mitigation of pathogenic threats. Construction began on the facility in 2011 with trial operations beginning in 2015.

Engineered openings that minimize the turbulence of transfer airflow, along with a mix of control strategies between labs and anchor spaces, are a best practice for achieving stable pressurization in biocontainment facilities. “The golden rule of containment is to always maintain the relationship between exhaust and supply,” says Michael Clements, director of life sciences at WorkingBuildings, LLC. “To keep a room contained, airflow fluctuations in the exhaust require a reaction in the supply in order to maintain this critical relationship.”