Biocontainment

Nationwide Children's Hospital is constructing a $100 million gene therapy manufacturing center in Columbus, Ohio. The 185,000-sf facility will enable Andelyn Biosciences, a for-profit subsidiary of Nationwide Children's, to supply pharmaceutical and biotechnology companies with genetic material for use in research and clinical trials. Located in The Ohio State University's Innovation District, the leased structure will feature advanced cGMP environments for commercial-scale manufacturing.

The life sciences industry has become the great hope in real estate, as we face the most significant public health crisis in a century. While other industries have slowed and suffered as a result of sheltering in place and working from home, science facilities have remained operational and even have thrived in prime markets, as the industry continues to search for medical breakthroughs. The downturn in other industries has left buildings vacant. The life science market, on the other hand, continues to experience some of the lowest vacancy and highest employment rates. For life science organizations in the prime U.S. markets, there simply remains a shortage of available research-capable space. Enter the big pivot to science.

ApiJect will break ground in December of 2020 on the Gigafactory campus in Durham, N.C. Strategically sited in Research Triangle Park, the complex will be the world’s largest pharmaceutical fill-finish facility, offering an annual production capacity of three billion single-dose prefilled injectors. Funded by a federal loan of $590 million, the one million-sf project will provide BSL-2 manufacturing areas, cold and ultra-cold storage infrastructure, and an onsite needle and cannula factory.

Iowa State University broke ground in October of 2020 on the $75 million Veterinary Diagnostic Laboratory (VDL) in Ames. Located on the campus of the College of Veterinary Medicine, the 72,540-sf structure will provide leading-edge labs and testing suites to enable the prevention, detection, and mitigation of animal diseases including avian influenza, African Swine Fever, and porcine epidemic diarrhea virus.

The unprecedented health and economic impact of the COVID-19 pandemic is driving many institutions to increase investment in new biocontainment facilities or rapidly pivot to upgrade and repurpose existing containment spaces in an urgent attempt to respond to the crisis. Hundreds of organizations nationwide began applying for grants after the National Institutes for Health (NIH) received $3.6 billion in funding dedicated to COVID-19 research as part of an emergency stimulus bill passed earlier this year. The NIH now has until 2024 to release the funds. Additionally, private donors, non-governmental organizations, and other entities worldwide are providing billions in funding for development of testing and vaccine programs. This surge of financing is expected to fuel a growth in the creation of new biocontainment spaces in the near future and long term. Since designing, building, and commissioning new biocontainment labs is an expensive and time-consuming process, some institutions are electing to upgrade existing BSL-2 facilities to make them BSL-3, while others are choosing to move existing research programs to make room for new pandemic-related initiatives.

The University of Wisconsin-Madison opened the $57.1 million Meat Science and Animal Biologics Discovery Building in November of 2020. Designed by Potter Lawson, the 67,540-gsf facility provides the College of Agricultural and Life Sciences with leading-edge environments for research, teaching, and outreach. The two-story structure houses two technology-rich lecture halls, a shared research lab, an expansive atrium, demonstration areas, conference rooms, faculty offices, and a retail meat store.

The University of Nebraska Medical Center dedicated the Dr. Edwin G. & Dorothy Balbach Davis Global Center in October of 2020 in Omaha. Serving as the headquarters for the Interprofessional Experiential Center for Enduring Learning (iEXCEL), the $122 million facility provides advanced simulation environments where students can master clinical skills in real-world settings.

SSM Health opened the $550 million Saint Louis University Hospital in September of 2020. Designed to elevate the patient experience, the 802,000-sf academic medical center offers 316 private patient rooms, a spacious intensive care unit, and an expanded Level I trauma center and emergency department. Leveraging advanced technologies to mitigate the spread of infectious diseases, the nine-story facility features a sophisticated building automation system that can provide negative air pressure in many areas.

The Bolivian National Service of Agricultural Health and Food Safety is planning to build a 201,076-sf research campus in Santa Cruz. Strengthening the country’s research and diagnosis capacity for veterinary, phytosanitary, and food safety challenges, the state-of-the-art complex will provide four laboratory buildings for animal health, plant health, food safety, and fruit fly research, as well as an administrative center.

JAC Construction and its sister company Level 3 Design Group are partnering with Industrial Commercial Systems and Ultraviolet Devices (UVDI) to bring an advanced UV-C air disinfection solution to commercial and hospitality markets. The program, StayProtected, is a comprehensive approach that combines leading technology with holistic methods to help prevent the airborne transmission of viruses, including SARS-CoV-2.

Fujifilm Diosynth Biotechnologies broke ground in August of 2020 on the $55 million Advanced Therapies Innovation Center in College Station, Texas. Representing an expansion of Fujifilm's cGMP manufacturing campus, the 60,000-sf facility will feature dedicated labs for process development and innovation. Research environments with BSL-2 capabilities will integrate advanced technologies for upstream, downstream, and analytical development.

Nagasaki University is planning to build a BSL-4 laboratory for SARS-CoV-2 research. The biocontainment facility will be located in an eight-story, 43,000-sf building providing specialized environments for the detection, study, and mitigation of infectious diseases. A dedicated area will accommodate novel coronavirus research. The Japanese government is expected to award $9.5 million in funding for fiscal year 2021 towards the construction of the project, which will also support training programs and the development of human resources.

Cleveland Clinic Florida opened the 107,000-sf Florida Research & Innovation Center in July of 2020 in Port St. Lucie. Accelerating the translation of medical discoveries into innovative therapeutics for clinical treatment, the facility will provide leading-edge laboratories for research programs in immuno-oncology and infectious diseases, such as Zika virus and SARS-CoV-2. The center includes BSL-3 biocontainment suites, administrative offices, meeting rooms, and an area for training programs. 

Communities, corporations, and educational institutions are drafting plans to reopen during the COVID-19 pandemic, employing policies around personal protective equipment; keeping a 6-foot distance from co-workers, peers, and clients; and reconfiguring their physical spaces. Another potential mitigation strategy is to adjust a facility’s mechanical system to better protect the occupants, though that should not be considered the primary solution, cautions Michael Walsh, PE, LEED AP, senior mechanical engineer and principal at R.G. Vanderweil Engineers, LLP. “There’s no silver bullet,” he says.

The Centers for Disease Control and Prevention (CDC) will begin construction in early 2021 on the 160,000-sf High Containment Continuity Laboratory in Atlanta. Designed by a joint venture of Flad Architects and Page, the BSL-4 facility will support the CDC's mission to rapidly detect and mitigate public health hazards. Accommodating approximately 80 investigators, the state-of-the-art laboratory will be one of three centers in the world designed and certified to facilitate diagnostic research on specific, select viruses.