Big energy-hogging tools are needed to compute the smallest matter on earth, and the space needs of new-frontier science initiatives are taxing administrators, faculty, and facility teams. Here you’ll see the kind of property commitments and dedicated research facilities that leading institutions are investing in for high-demand programs including quantum technology and semiconductor research. Session leaders illustrate the capabilities and limitations of existing campus infrastructures to support next-gen research and fab facilities, and criteria for making renovate/build decisions. They set out the sustainability challenges presented, options and implications of new environmental controls, and how to adapt spaces to work for emerging science and technologies.